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1

Comparison of Hepatic-like Cell Production from Human Embryonic Stem Cells and Adult Liver Progenitor Cells: CAR Transduction Activates a Battery of Detoxification Genes

Natalie Funakoshi, Cédric Duret, Jean-Marc Pascussi, Pierre Blanc, Patrick Maurel, Martine Daujat-Chavanieu, Sabine Gerbal-Chaloin

Journal:

Stem Cell Reviews and Reports

Year:

2011

Language:

english

File:

PDF, 610 KB

english, 2011

2

The Tangle of Nuclear Receptors that Controls Xenobiotic Metabolism and Transport: Crosstalk and Consequences

Pascussi, Jean-Marc, Gerbal-Chaloin, Sabine, Duret, Cédric, Daujat-Chavanieu, Martine, Vilarem, Marie-José, Maurel, Patrick

Journal:

Annual Review of Pharmacology

Year:

2008

Language:

english

File:

PDF, 240 KB

english, 2008

3

CYP1A1 Induction in the Colon by Serum: Involvement of the PPARα Pathway and Evidence for a New Specific Human PPREα Site

Villard, Pierre-Henri, Barlesi, Fabrice, Armand, Martine, Dao, Thi-Mai-Anh, Pascussi, Jean-Marc, Fouchier, Francis, Champion, Serge, Dufour, Claire, Giniès, Christian, Khalil, Ayman, Amiot, Marie-Jose

Journal:

Year:

2011

Language:

english

File:

PDF, 659 KB

english, 2011

4

Interleukin 1β inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance

Eric Assenat, Sabine Gerbal-Chaloin, Dominique Larrey, Jean Saric, Jean-Michel Fabre, Patrick Maurel, Marie-José Vilarem, Jean Marc Pascussi

Journal:

Year:

2004

Language:

english

File:

PDF, 1.16 MB

english, 2004

5

Interleukin 1β inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance

Eric Assenat, Sabine Gerbal-Chaloin, Dominique Larrey, Jean Saric, Jean-Michel Fabre, Patrick Maurel, Marie-José Vilarem, Jean Marc Pascussi

Journal:

Year:

2004

Language:

english

File:

PDF, 327 KB

english, 2004

6

Novel aspects of PPARα-mediated regulation of lipid and xenobiotic metabolism revealed through a nutrigenomic study

Pascal G. P. Martin, Hervé Guillou, Frédéric Lasserre, Sébastien Déjean, Annaig Lan, Jean-Marc Pascussi, Magali SanCristobal, Philippe Legrand, Philippe Besse, Thierry Pineau

Journal:

Year:

2007

Language:

english

File:

PDF, 705 KB

english, 2007

7

Differential regulation of constitutive androstane receptor expression by hepatocyte nuclear factor4α isoforms

Jean Marc Pascussi, Agnes Robert, Amelie Moreau, Jeanne Ramos, Paulette Bioulac-Sage, Francis Navarro, Pierre Blanc, Eric Assenat, Patrick Maurel, Marie Jose Vilarem

Journal:

Year:

2007

Language:

english

File:

PDF, 498 KB

english, 2007

8

Interplay between cholesterol and drug metabolism

Tadeja Rezen, Damjana Rozman, Jean-Marc Pascussi, Katalin Monostory

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2011

Language:

english

File:

PDF, 748 KB

english, 2011

9

N-1H-Benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists

Cindy Benod, Guy Subra, Virginie Nahoum, Aude Mallavialle, Jean-François Guichou, Julien Milhau, Samuel Roblés, William Bourguet, Jean-Marc Pascussi, Patrick Balaguer, Alain Chavanieu

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 500 KB

english, 2008

10

Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes : Sequential role of glucocorticoid receptor and pregnane X receptor

Jean-Marc Pascussi, Lionel Drocourt, Sabine Gerbal-Chaloin, Jean-Michel Fabre, Patrick Maurel, Marie-José Vilarem

Journal:

Year:

2001

Language:

english

File:

PDF, 1.12 MB

english, 2001

11

Regulation of Xenobiotic Detoxification by Nuclear Receptors

JM Pascussi, S Gerbal-Chaloin, L Drocourt, L Pichard-Garcia, MJ Vilarem, P Maurel

Journal:

Medicinal Chemistry Research

Year:

2004

File:

PDF, 437 KB

2004

12

Transcriptional regulation of the human CYP46A1 brain-specific expression by Sp transcription factors

Inês Milagre, Maria João Nunes, Maria João Gama, Rui Fernando Silva, Jean Marc Pascussi, Maria C. Lechner, Elsa Rodrigues

Journal:

Journal of Neurochemistry

Year:

2008

Language:

english

File:

PDF, 942 KB

english, 2008

13

Reply to Rifampicin: a glucocorticoid receptor ligand?

Calleja, C., Pascussi, J.M., Mani, J.C., Maurel, P., Vilarem, M.J.

Journal:

Nature Medicine

Year:

1998

Language:

english

File:

PDF, 31 KB

english, 1998

14

The antibiotic rifampicin is a nonsteroidal ligand and activator of the human glucocorticoid receptor

Calleja, C., Pascussi, J.M., Mani, J.C., Maurel, P., Vilarem, M.J.

Journal:

Nature Medicine

Year:

1998

File:

PDF, 475 KB

1998

15

Vitamin D–Resistant Rickets and Type 1 Diabetes in a Child With Compound Heterozygous Mutations of the Vitamin D Receptor (L263R and R391S): Dissociated Responses of the CYP-24 and rel-B Promoters to 1,25-Dihydroxyvitamin D3

Minh Nguyen, Arnold d'Alesio, Jean Marc Pascussi, Rajiv Kumar, Matthew D Griffin, Xiangyang Dong, Huguette Guillozo, Marthe Rizk-Rabin, Christiane Sinding, Pierre Bougnères, Frédéric Jehan, Michèle Ga

Journal:

Journal of Bone and Mineral Research

Year:

2006

Language:

english

File:

PDF, 1.68 MB

english, 2006

16

The Effects of Rosuvastatin and the CYP51A1 Inhibitor LEK-935 on the Proteome of Primary Human Hepatocytes

Worner, M., Melchior, K., Monostory, K., Pascussi, J.-M., Huber, C. G., Bernhardt, R.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 194 KB

english, 2012

17

Di-(2-ethylhexyl)-phthalate (DEHP) activates the constitutive androstane receptor (CAR): A novel signalling pathway sensitive to phthalates

Alexandre Eveillard, Laïla Mselli-Lakhal, Ariane Mogha, Frédéric Lasserre, Arnaud Polizzi, Jean-Marc Pascussi, Hervé Guillou, Pascal G.P. Martin, Thierry Pineau

Journal:

Biochemical Pharmacology

Year:

2009

Language:

english

File:

PDF, 633 KB

english, 2009

18

Disruption of microtubules leads to glucocorticoid receptor degradation in HeLa cell line

Zdeněk Dvořák, Martin Modrianský, Jitka Ulrichová, Patrick Maurel, Marie-Jose Vilarem, Jean-Marc Pascussi

Journal:

Cellular Signalling

Year:

2005

Language:

english

File:

PDF, 788 KB

english, 2005

19

Microtubules-interfering agents restrict aryl hydrocarbon receptor-mediated CYP1A2 induction in primary cultures of human hepatocytes via c-jun-N-terminal kinase and glucocorticoid receptor

Radim Vrzal, Martine Daujat-Chavanieu, Jean-Marc Pascussi, Jitka Ulrichova, Patrick Maurel, Zdenek Dvorak

Journal:

European Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 1.44 MB

english, 2008

20

Cytoprotective properties of α-tocopherol are related to gene regulation in cultured d-galactosamine-treated human hepatocytes

Raul González, Juan Antonio Collado, Sandra Nell, Javier Briceño, María José Tamayo, Enrique Fraga, Ángel Bernardos, Pedro López-Cillero, Jean Marc Pascussi, Sebastián Rufián, Marie-José Vilarem, Manu

Journal:

Free Radical Biology and Medicine

Year:

2007

Language:

english

File:

PDF, 902 KB

english, 2007

21

Evidence for the Presence of a Functional Pregnane X Receptor Response Element in the CYP3A7 Promoter Gene

Jean-Marc Pascussi, Youssef Jounaidi, Lionel Drocourt, Jacques Domergue, Charles Balabaud, Patrick Maurel, Marie-Josée Vilarem

Journal:

Biochemical and Biophysical Research Communications

Year:

1999

Language:

english

File:

PDF, 121 KB

english, 1999

22

Interleukin-6 Negatively Regulates the Expression of Pregnane X Receptor and Constitutively Activated Receptor in Primary Human Hepatocytes

Jean-Marc Pascussi, Sabine Gerbal-Chaloin, Lydiane Pichard-Garcia, Martine Daujat, Jean-Michel Fabre, Patrick Maurel, Marie-José Vilarem

Journal:

Biochemical and Biophysical Research Communications

Year:

2000

Language:

english

File:

PDF, 209 KB

english, 2000

23

Constitutive androstane receptor–vitamin D receptor crosstalk: Consequence on CYP24 gene expression

Amélie Moreau, Patrick Maurel, Marie-José Vilarem, Jean-Marc Pascussi

Journal:

Biochemical and Biophysical Research Communications

Year:

2007

Language:

english

File:

PDF, 284 KB

english, 2007

24

Is nuclear factor kappa-B the missing link between inflammation, cancer and alteration in hepatic drug metabolism in patients with cancer?

Eric Assenat, Sabine Gerbal-chaloin, Patrick Maurel, Marie José Vilarem, Jean Marc Pascussi

Journal:

European Journal of Cancer

Year:

2006

Language:

english

File:

PDF, 167 KB

english, 2006

25

Zearalenone activates pregnane X receptor, constitutive androstane receptor and aryl hydrocarbon receptor and corresponding phase I target genes mRNA in primary cultures of human hepatocytes

Imen Ayed-Boussema, Jean Marc Pascussi, Patrick Maurel, Hassen Bacha, Wafa Hassen

Journal:

Environmental Toxicology and Pharmacology

Year:

2011

Language:

english

File:

PDF, 480 KB

english, 2011

26

Identification of proteomic changes during human liver development by 2D-DIGE and mass spectrometry

Jean Paul Brizard, Jeanne Ramos, Agnés Robert, Daniel Lafitte, Nicole Bigi, Pierre Sarda, Dalila Laoudj-Chenivesse, Francis Navarro, Pierre Blanc, Eric Assenat, Patrick Maurel, Jean-Marc Pascussi, Mar

Journal:

Journal of Hepatology

Year:

2009

Language:

english

File:

PDF, 785 KB

english, 2009

27

The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors

J.M. Pascussi, S. Gerbal-Chaloin, L. Drocourt, P. Maurel, M.J. Vilarem

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2003

Language:

english

File:

PDF, 217 KB

english, 2003

28

Discovery of a Highly Active Ligand of Human Pregnane X Receptor: A Case Study from Pharmacophore Modeling and Virtual Screening to "In Vivo" Biological Activity

Lemaire, G., Benod, C., Nahoum, V., Pillon, A., Boussioux, A.-M., Guichou, J.-F., Subra, G., Pascussi, J.-M., Bourguet, W., Chavanieu, A., Balaguer, P.

Journal:

Molecular Pharmacology

Year:

2007

Language:

english

File:

PDF, 586 KB

english, 2007

29

Xenoreceptors CAR and PXR Activation and Consequences on Lipid Metabolism, Glucose Homeostasis, and Inflammatory Response

Moreau, Amélie, Vilarem, Marie José, Maurel, Patrick, Pascussi, Jean Marc

Journal:

Molecular Pharmaceutics

Year:

2008

Language:

english

File:

PDF, 216 KB

english, 2008

30

The mycotoxin, patulin, increases the expression of PXR and AhR and their target cytochrome P450s in primary cultured human hepatocytes

Ayed-Boussema, Imen, Pascussi, Jean Marc, Rjiba, Karima, Maurel, Patrick, Bacha, Hassen, Hassen, Wafa

Journal:

Drug and Chemical Toxicology

Year:

2012

Language:

english

File:

PDF, 1.04 MB

english, 2012

31

Estrogens and antiestrogens activate hPXR

Wissem Mnif, Jean-Marc Pascussi, Arnaud Pillon, Aurélie Escande, Aghleb Bartegi, Jean-Claude Nicolas, Vincent Cavaillès, Marie-Josèphe Duchesne, Patrick Balaguer

Journal:

Toxicology Letters

Year:

2007

Language:

english

File:

PDF, 768 KB

english, 2007

32

Effects of the mycotoxins aflatoxin B1, zearalenone and ochratoxine A on nuclear receptors PXR, CAR and AhR expression and corresponding CYP 450 in primary cultured human hepatocytes

Wafa Hassen, Imen Ayed-Boussema, Jean-Marc Pascussi, Patrick Maurel, Hassen Bacha, Hassen Wafa

Journal:

Toxicology Letters

Year:

2009

Language:

english

File:

PDF, 67 KB

english, 2009

33

Evidence for a new human CYP1A1 regulation pathway involving PPAR-α and 2 PPRE sites

E. Sérée, P.-H. Villard, J.-M. Pascussi, T. Pineau, P. Maurel, Q.B. Nguyen, F. Fallone, P.-M. Martin, S. Champion, B. Lacarelle, J.-F. Savouret, Y. Barra

Journal:

Gastroenterology

Year:

2004

Language:

english

File:

PDF, 526 KB

english, 2004

34

Pregnane × Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation

Caroline Raynal, Jean-Marc Pascussi, Géraldine Leguelinel, Cyril Breuker, Jovana Kantar, Benjamin Lallemant, Sylvain Poujol, Caroline Bonnans, Dominique Joubert, Frédéric Hollande, Serge Lumbroso, Jea

Journal:

Molecular Cancer

Year:

2010

Language:

english

File:

PDF, 1.80 MB

english, 2010

35

Ochratoxin A induces CYP3A4, 2B6, 3A5, 2C9, 1A1, and CYP1A2 gene expression in primary cultured human hepatocytes: a possible activation of nuclear receptors

Ayed-Boussema, Imen, Pascussi, Jean Marc, Zaied, Chiraz, Maurel, Patrick, Bacha, Hassen, Hassen, Wafa

Journal:

Drug and Chemical Toxicology

Year:

2012

Language:

english

File:

PDF, 1.19 MB

english, 2012

36

P3-242: Role of Sp proteins in the transcriptional regulation of the brain-specific CYP46A1 gene

Milagre, Inês, Nunes, Maria João, Gama, Maria João, Silva, Rui F., Pascussi, Jean Marc, Lechner, Maria Celeste, Rodrigues, Elsa

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 68 KB

english, 2008

37

Integrated Comparison of Drug-Related and Drug-Induced Ultra Performance Liquid Chromatography/Mass Spectrometry Metabonomic Profiles Using Human Hepatocyte Cultures

Croixmarie, Vincent, Umbdenstock, Thierry, Cloarec, Olivier, Moreau, Amélie, Pascussi, Jean-Marc, Boursier-Neyret, Claire, Walther, Bernard

Journal:

Analytical Chemistry

Year:

2009

Language:

english

File:

PDF, 1.45 MB

english, 2009

38

Pathophysiological Factors Affecting CAR Gene Expression

Pascussi, Jean Marc, Dvorák, Zdenek, Gerbal-Chaloin, Sabine, Assenat, Eric, Maurel, Patrick, Vilarem, Marie José

Journal:

Drug Metabolism Reviews

Year:

2003

Language:

english

File:

PDF, 257 KB

english, 2003

39

Effect of Aflatoxin B1 on Nuclear Receptors PXR, CAR, and AhR and Their Target Cytochromes P450 mRNA Expression in Primary Cultures of Human Hepatocytes

Ayed-Boussema, I., Pascussi, J.-M., Maurel, P., Bacha, H., Hassen, W.

Journal:

International Journal of Toxicology

Year:

2012

Language:

english

File:

PDF, 486 KB

english, 2012

40

Effect of status epilepticus and antiepileptic drugs on CYP2E1 brain expression

Boussadia, B., Ghosh, C., Plaud, C., Pascussi, J.M., de Bock, F., Rousset, M.C., Janigro, D., Marchi, N.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.80 MB

english, 2014

41

Tyrosine 319 in the Interdomain B of ZAP-70 Is a Binding Site for the Src Homology 2 Domain of Lck

Pelosi, M., Di Bartolo, V., Mounier, V., Mege, D., Pascussi, J.-M., Dufour, E., Blondel, A., Acuto, O.

Journal:

Journal of Biological Chemistry

Year:

1999

Language:

english

File:

PDF, 895 KB

english, 1999

42

Dehydroepiandrosterone Induces Human CYP2B6 through the Constitutive Androstane Receptor

Kohalmy, K., Tamasi, V., Kobori, L., Sarvary, E., Pascussi, J.-M., Porrogi, P., Rozman, D., Prough, R. A., Meyer, U. A., Monostory, K.

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 344 KB

english, 2007

43

Drug Interaction Potential of 2-((3,4-Dichlorophenethyl)(propyl)amino)-1-(pyridin-3-yl)ethanol (LK-935), the Novel Nonstatin-Type Cholesterol-Lowering Agent

Monostory, K., Pascussi, J.-M., Szabo, P., Temesvari, M., Kohalmy, K., Acimovic, J., Kocjan, D., Kuzman, D., Wilzewski, B., Bernhardt, R., Kobori, L., Rozman, D.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 295 KB

english, 2009

44

Inhibition of Human Sterol 7-Reductase and Other Postlanosterol Enzymes by LK-980, a Novel Inhibitor of Cholesterol Synthesis

Acimovic, J., Korosec, T., Seliskar, M., Bjorkhem, I., Monostory, K., Szabo, P., Pascussi, J.-M., Belic, A., Urleb, U., Kocjan, D., Rozman, D.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 251 KB

english, 2011

45

Hormonal regulation of CYP1A expression

Monostory, Katalin, Pascussi, Jean-Marc, Kóbori, László, Dvorak, Zdenek

Journal:

Drug Metabolism Reviews

Year:

2009

Language:

english

File:

PDF, 1.01 MB

english, 2009

46

Serum-Derived Hepatitis C Virus Infection of Primary Human Hepatocytes Is Tetraspanin CD81 Dependent

Molina, S., Castet, V., Pichard-Garcia, L., Wychowski, C., Meurs, E., Pascussi, J.-M., Sureau, C., Fabre, J.-M., SaCunha, A., Larrey, D., Dubuisson, J., Coste, J., McKeating, J., Maurel, P., Fournier-

Journal:

Journal of Virology

Year:

2008

Language:

english

File:

PDF, 246 KB

english, 2008

47

Dexamethasone-Mediated Up-Regulation of Human CYP2A6 Involves the Glucocorticoid Receptor and Increased Binding of Hepatic Nuclear Factor 4 to the Proximal Promoter

Onica, T., Nichols, K., Larin, M., Ng, L., Maslen, A., Dvorak, Z., Pascussi, J.-M., Vilarem, M.-J., Maurel, P., Kirby, G. M.

Journal:

Molecular Pharmacology

Year:

2007

Language:

english

File:

PDF, 428 KB

english, 2007

48

R82: Rôle du récepteur des xénobiotiques CAR (Constitutive Androstane Receptor, NR1I3) dans la réponse cellulaire à la chimiothérapie du cancer colorectal

Leguelinel, G., Évrard, A., Kantar, J., Breuker, C., Lallemant, B., Poujol, S., Joubert, D., Hollande, F., Lumbroso, S., Brouillet, J.P., Pascussi, J.M.

Journal:

Bulletin du Cancer

Year:

2010

Language:

french

File:

PDF, 78 KB

french, 2010

49

Transcriptional Analysis of the Orphan Nuclear Receptor Constitutive Androstane Receptor (NR1I3) Gene Promoter: Identification of a Distal Glucocorticoid Response Element

Pascussi, Jean Marc, Busson-Le Coniat, Maryvonne, Maurel, Patrick, Vilarem, Marie-José

Journal:

Molecular Endocrinology

Year:

2003

Language:

english

File:

PDF, 419 KB

english, 2003

50

Transcriptional Regulation of CYP2C9 Gene: ROLE OF GLUCOCORTICOID RECEPTOR AND CONSTITUTIVE ANDROSTANE RECEPTOR

Gerbal-Chaloin, S., Daujat, M., Pascussi, J.-M., Pichard-Garcia, L., Vilarem, M.-J., Maurel, P.

Journal:

Journal of Biological Chemistry

Year:

2002

Language:

english

File:

PDF, 702 KB

english, 2002